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Information × Registration Number 0213U005806, 0110U006269 , R & D reports Title Ion channels and calcium homeostasis as the targets of modulatory influence of endo- and exogenous biological active substances. popup.stage_title Head Shuba Yaroslav M., Доктор біологічних наук Registration Date 25-07-2013 Organization International center of molecular physiology popup.description2 In this study we investigated the effect of ATP channel activator - flokalin - fluorinated analog of pinacidil on the electrical excitability of cultured neonatal cardiomyocytes from different parts of the rat heart, to the recombinant heart ATP channels which are heterologicaly expressed in human embryonic kidney cell line (HEK 293b) and sodium and calcium currents of cardiomyocytes . Our data show that flokalin really is an effective inhibitor of electrical and contractile activity of cardiomyocytes due to the "discovery" cardiac ATP channels and that his property may largely underlie cardioprotection. However, flokalin was also able to block voltage-sensitive sodium and high-activated calcium channels, but because it is his side property must be taken into account when determining the therapeutic dose of the drug when it is used as a cardioprotector. Product Description popup.authors Войтичук О.І. Соткіс Г.В. popup.nrat_date 2020-04-02 Close