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Information × Registration Number 0213U005807, 0110U006269 , R & D reports Title Ion channels and calcium homeostasis as the targets of modulatory influence of endo- and exogenous biological active substances. popup.stage_title Head Shuba Yaroslav M., Доктор біологічних наук Registration Date 25-07-2013 Organization International center of molecular physiology popup.description2 The effects of recombinant endothelial monocyte-activating polypeptide II (EMAP II) stabilized by dextran 70 were studied in cultured LNCaP human prostate cancer cells. EMAP II present in the culture medium at concentrations of 10-5, 10-4 or 10-3 mg/ml dose-dependently inhibited the cell's growth due tostimulation of apoptosis and, perhaps, due to inhibition of cell proliferation. Enhancement of LNCaP cells apoptosis was evidenced by the appearance of the apoptotic bodies and nuclear DNA defragmentation, as assayed by TUNEL method. Thus, our study demonstrates for the first time the ability of the human recombinant EMAP II to inhibit growth of non-stimulated cancer cells in vitro without involvement of its well known antiangiogenic effect. Product Description popup.authors Войтичук О.І. Соткіс Г.В. popup.nrat_date 2020-04-02 Close