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Registration Number

0213U005895, 0110U005707 , R & D reports

Title

Membrane transport system and antioxidant system of coldblooded embryos

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Head

Sanagursky Dmytro Ivanovych,

Registration Date

25-09-2013

Organization

Ivan Franko National University of Lviv

Description

Intended to study membrane related processes of loach embryo Misgurnus fossilis L. under the effect of amino acid derivatives of 1,4-naphthoquinone. There have been shown dose-dependent inhibition of embryos of Na+, K+-ATPase amino acid derivatives of 1,4-naphthoquinone. It was revealed that the degree of inhibition impact depends on the stage of embryo development, the structure of corresponding amino acids derivatives of 1,4-naphthoquinone and the sensitivity of Na+, K+-ATPase to the action of the examined substances. There were defined constants of half-inhibition I50 for amino acids derivatives of 1,4-naphthoquinone. The analysis in Dixon coordinates showed the conditionally competitive type of inhibition. The results of ATPase inhibition confirmed changes of the TMP, the ultrastructure and the morphology of blastomeres of embryos.

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Бура Марта Володимирівна
Галан Марія Богданівна
Генега Анастасія Богданівна
Головчак Наталя Петрівна
Дика Марія Василівна
Отчич Віра Петрівна
Санагурський Дмитро Іванович
Тарновська Антоніна Володимирівна