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Registration Number

0213U006587, 0113U007522 , R & D reports

Title

Characterization of new biomarkers of human glial tumors

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Head

Kavsan Vadym Musiyovich,

Registration Date

11-12-2013

Organization

Institute of Molecular Biology and Genetics of NASU

Description

The aim of the project is tру classification of glial tumors based on the analysis of gene expression at the RNA level and characterization of novel biomarkers of glial tumors, encoded by differentially expressed genes. The comparison of the SAGE and microarray analysis identified 30 genes, 5 - fold changes of the expression of which in glioblastoma, the most malignant stage of development of astrocytic gliomas as compared to normal brain, confirmed by both methods. RNA analysis of surgical specimens confirmed gene expression changes in glioblastoma compared to normal human brain. 474 genes with a heterogeneous distribution of the expression in glioblastomas were identified by entropy analysis. 92 genes whose expression distribution in glioblastomas is twomodal. Data on the expression of these genes in the individual glioblastoma samples will be used for determining of molecular subgroups of them.

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Єршов Антон Вікторович
Авдєєв Станіслав Сергійович
Арешков Павло Олександрович
Балинська Олена Вікторівна
Бкреєва Тетяна Василівна
Дмитренко Володимир Володимирович
Чаусовський Тімур Йосипович