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Registration Number

0213U006588, 0110U006127 , R & D reports

Title

Development of the system for growth inhibition of brain tumors on the basis of nanoconjugates of antisens-oligonucleotides and antibody, specific for oncoproteins, with natural bioplymers

Head

Kavsan Vadym Moiseevitch,

Registration Date

11-12-2013

Organization

Institute of Molecular Biology and Genetics

Description

The aim of the project is development and creation of the system for the suppression of the growth of brain glial tumors by nanoconjugates with new effective targeted antitumor drugs. It will be created nanoconjugates of natural polymer poly-beta-malic acid (poly-malic acid, PMLA) from microorganism Physarum polycephalum, with antisense CHI3L1 mRNA oligonucleotides or CHI3L1-siRNA, and other functional modules. Nanoconjugates will be used in in vitro experiments for the antisense inhibition of protein target. Проведено синтез нанокон'югатів з антисенс-олігонуклеотидами до CHI3L1 і перевірку здатності антисенс-олігонуклеотидів до CHI3L1 інгібувати ріст клітин. Synthesis of PMLA nanoconjugates with particular functional modules, their purification and examination of the structure was carried out during third stage of the project fullfilment. Synthesis of nanoconjugates with antisense oligonucleotides to CHI3L1 and examination of the possibility of antisense oligonucleotides to CHI3L1 to inhibit cell growth was carried out.

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Єршов Антон Вікторович
Балинська Олена Вікторівна
Дмитренко Володимир Володимирович
Дубей Лариса Василівна
Костенко Олександр Миколайович