Search academic texts

Information × Registration Number 0213U006835, 0110U005771 , R & D reports Title Construction of cancer vaccines based on tumor cells and hest shock proteins popup.stage_title Head Potebnya Grygory Platonovych, Registration Date 09-01-2014 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 It was obtained combined antitumor vaccine which contained HSP complexes which are derived from tumor tissue after hyperthermic influence and chicken embryonic tissue. The application of such vaccine far more effective as compared to application, vaccines prepared with the use of separate components of mixture. As adjuvant for constructing of such vaccines used citotoxic metabolit with molecular weight of 70 kDa which is obtained from the growth medium B. subtilis B- 7025. The application of such vaccines considerably inhibits the formation of metastases in experimental animals. The analysis of immune effects induced by vaccine therapy was suggested that realization of vaccines' antineoplastic action is carried out due to a high level of reactions mediated by the cells of macrophagal and lymphoid branches. Product Description popup.authors Болюх Ірина Анатоліївна Діденко Геннадій Васильович Потебня Григорій Платонович Сергієнко Тетяна Карлівна Шпак Євген Григорович popup.nrat_date 2020-04-02 Close