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Information × Registration Number 0213U006868, 0110U005770 , R & D reports Title Development of biotherapy drugs (biomolecules) by RNA-based technologies to correct molecular disorders found in tumor cells popup.stage_title Head Chekhun Vasyl Fedorovych, Registration Date 09-01-2014 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 We studied features of epigenetic regulation of endogenous iron metabolism proteins in breast cancer cells of different molecular subtypes. We found that human breast cancer cells of the most aggressive basal subtype (MDA-MB-231 and MDA-MB-468) are characterized by hypomethylation of light and heavy ferritin chains genes and significant reduction of miRNA 133а and 200b expression, which take part in regulation of expression of these proteins. We showed that mentioned changes in epigenetic regulation of iron metabolism proteins caused elevation of reactive oxygen species generation and raise of unbound iron pool levels. The acquired fundamental data might be a basis for use of miRNA 133а and 200b as breast cancer markers of prognosis and aggressiveness. Product Description popup.authors Бездєнєжних Наталія Олександрівна Борікун Тетяна Володимирівна Кунська Любов Миколаївна Лук'янова Наталія Юріївна Мельник Наталі Миколаївна Налєскіна Леся Анатоліівна Чехун Василь Федорович Чехун Святослав Васильович popup.nrat_date 2020-04-02 Close