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Information × Registration Number 0213U007129, 0110U001187 , R & D reports Title To conduct complex epidemiologic, clinical and laboratory studies of the role of bioactive trace elements as possible risk factors of developing DM type 1 and its complications. popup.stage_title Head Kravchenko Victor Ivanovich, Registration Date 05-04-2013 Organization State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism оf the Academy of Medical Scienses of Ukraine" popup.description2 Study object: potential ethiological factors of type 1 diabetes (T1D) in Ukraine: Zinc and Iron levels in blood of T1D patients and healthy individuals, Zn content in drinking water, and prevalence of rs13266634 (Arg325Trp) mutation of Zinc type 8 (ZnT8)gene-transporter SLC30A8 in Ukraine's regions with different prevalence of T1D.Aim: to identify factors that affect the territorial heterogeneity of T1D prevalence.Methods:The following tests were performed: blood Zinc (Zn) and Iron (Fe), glucose (G) and glycated hemoglobin (HbA1c), antibodies to glutamic acid decarboxylase (GADA), genotyping for rs13266634 gene ZnT8 SLC30A8 in the blood of patients and healthy individuals, residing in 4 regions that belong to different territorial clusters, marked accoddrding to T1D prevalence: Zaporizhzhya and Chernihiv - maximum (Max), Chernivtsi and Ivano-Frankivsk - minimum (Min) clusters. Result of the study: Zn but not Fe level is significantly higher in plasma of Max cluster residents, irrespective of T1D, comparing to Min cluster residents. Zn plasma levels in T1D patients and persons without diabetes did not differ. Average Zn level in T1D patients and healthy individualsin Zaporizhzhya region is higher than in residents of 3 other studied regions of Ukraine. These differences are not due to Zn content in drinking water. Zn levels in diabetic patients without foot ulcers were higher than in patients with ulcers.T1D patients had higher Zn levels than T2D patients. We revealed a negative correlation between the levels of Zn and HbA1 and demonstrated a possibility to pharmacologically correct low Zn plasma and erythrocyte levels. We have proven the significance of rs13266634 (Arg325Trp) mutation of Zinc type 8 (ZnT8) transporter gene-SLC30A8 as a risk factor for T1D for residents of Chernihivska, but not for 3 other studied regions. We have obtained data about possible relation of SLC30A8 polymorphism and autoimmune nature of DM.Conclusions: we were the first to indicate different levels of plasma Zn in residents of territories with different T1D prevalence; for the first time the significance of ZnT8 SLC30A8 gene polymorphism as a T1D risk factor was shown, however this fact has territorial limitations. Together with our confirmed data on correlation of Zn levels and several clinical DM aspects, there is a need for further evaluation of this indicator’s practical significance. Degree of introduction: scientificarticles,patent. Field of application: endocrinology, сlinical diabetology. Product Description popup.authors Данилюк В.Г. Калеватих І.В. Ковтун В.А. Ковтун В.А. Кравченко В.І. Красніков В.І. Опанасенко О М. Охріменко Н.В. Трощинська Л.Г. Халангот М.Д. popup.nrat_date 2020-04-02 Close