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Information × Registration Number 0213U007893, 0113U004301 , R & D reports Title Identification of selective drug compounds that can inhibit the function of protein kinases D (PKD) - a new targets for anticancer therapy. Section 2: Testing of a new selective inhibitors of protein kinases PKD families for developing the effective anticancer drug compounds popup.stage_title Head Sidorenko Svitlana Pavlivna, Registration Date 30-12-2013 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 For the first time it was shown that the profile of CD150 isoforms in cell lines of glial origin is different from hematopoietic cells, since they were characterized by high level of nCD150 expression and low level (or absence)of mRNA encoding CD150 isoforms with conventional cytoplasmic tail. In order to create the experimental model systems with expression of nCD150 and mCD150 isoforms, the set of experiments was started. It was shown that in the DT40 model system the mCD150-mediated signaling pathways led to ERK1/2 activation and did not affect the Akt activation. Product Description popup.authors Гордієнко І.М. Ковалевська Л.М. Романець О.Л. Сидоренко С.П. Шлапацька Л.М. Юрченко М.Ю. popup.nrat_date 2020-04-02 Close