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Registration Number

0213U008049, 0111U006563 , R & D reports

Title

Development and implementation in practice genetic markers of susceptibility to breast cancer and prostate.

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Head

Zaporozhan Valery Nikolaevich,

Registration Date

03-12-2013

Organization

Odesa National Medical University

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Studied polymorphism frequency is associated with risk of non-hereditary prostate and breast cancer. Of the 16 SNP taken to study the susceptibility to breast cancer have been identified four loci associated with breast cancer risk in the genes TOX3 (Rs 3,803,662 ), FGFR2 (Rs 2,981,582 ), SLC4A7 (Rs 4,973,768 ), and MAP3K1 (Rs 889,312 ) . The relative risk for SLC4A7 (Rs 4,973,768 ) was 1.78 at p = 0,06. For the rest polymorphism relative risk approaching the authentic values. In prostate cancer, of 7 SNP identified a SNP polymorphism in the gene ZNF652 with 1.74 relative risk was close to statistically significant values ( p ? 0,055). These polymorphisms can be used to test the susceptibility to prostate cancer and breast cancer .

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Бубнов Владимир Вячеславович
Вербицкая Томара Георгиевна
Запорожан Валерий Николаевич
Омельчук Олександра Євгеновна
Поклад Ганна Миколаївна.