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Registration Number

0213U008225, 0111U002203 , R & D reports

Title

To investigate mechanism of motoneuron pathologic functional activity formation in posttraumatic spasticity syndrome

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Head

Tsymbaliuk Vitaliy Ivanovych,

Registration Date

26-12-2013

Organization

State institution ''Institute of Neurosurgery n.acad. AP. Romodanov NAMS of Ukraine''

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In this issue the authors justified the use of half-crossing model of rat spinal cord as a base to explore synndromu spasticity, studied the peculiarities of the electrical activity changes of neurons of the spinal joints and gelatinous substance of spinal cord in the formation of spasticity syndrome, revealed that its occurrence is associated with the complex process of reorganization of neuronal networks of spinal cord below the injury, which are influenced significantly by the implantation of macroporous hydrogel and transplantation of olfactory bulb cells into the zone of injury. Also, the issue explored the features of the formation of cerebellar syndrome of hypotonia, its immunological correlatives. According to the data obtained the authors assumed that there is congeniality between the spasticity formation mechanisms and neuropathic pain syndrome in spinal cord injury and the key role in it of long-term changes of gelatinous substance neuronal activity: oppressing the inhibitory (tonic) neurons' activity and increasing the excitatory (fasic) neurons' activity. In the case of spasticity syndrome the authors have also found the credible changes of some electrophysiological characteristics of small neurons in the spinal nodes which are homotopious to spasticity syndrome, which may indicate the reduction in both inhibitory and excitatory effects on gelatinous substance neurons. The latter should be considered as one of the first fundamental justifications of a number of methods of physical neurorehabilitation in various forms of spasticity syndrome, which are based on increased activity of sensory neurons in the spinal units.

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Величко О.М.
Веселова О.І.
Гридіна Н.Я.
Золотоверх О.М.
Колісниченко О.П.
Кротов В.В.
Медведєв В.В.
Сенчик Ю.Ю.
Татарчук М.М.
Цимбалюк В.І.

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2020-04-02