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Information × Registration Number 0213U008308, 0111U010127 , R & D reports Title To study the patogenetic mechanisms of immunological disorders caused by violation of gamma interferon production and reception in patients with destructive pulmonary tuberculosis popup.stage_title Head Rekalova Elena Myhaylovna, Registration Date 15-01-2014 Organization SO "National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine" popup.description2 Object - 70 patients with destructive pulmonary tuberculosis and 30 healthy subjects. Aim - development of technology use drugs interferon and inducers of patients with destructive pulmonary tuberculosis by examining variations in the interferon system disorders based on data analysis Analysis of specific and nonspecific immune resistance. Methods - clinical, immunological, statistics. Defined 3 types of violations of g-IFN, characterized: І - downregulation of receptors for interferon-gamma (IFN-gR1) lymphocytes, monocytes and granulocytes at low or normal levels of g-IFN, II - increase reception IFN-gR1 these cells in low or normal levels of g-IFN, III - reducing the reception IFN- gR1pry high levels of g- IFN, accompanied by inhibition of effector cell function. The technology of identifying additional criteria for assessing the functional state of circulating granulocytes and monocytes in the blood of patients with destructive pulmonary tuberculosis, which is to determine the density of IFN-gR1 in these cells. Expediency correction of violations through the use of immunomodulators - interferon inducers. Indications for their usage in patients with destructive pulmonary tuberculosis in addition to causal chemotherapy: reduced or reference level g-IFN serum reduced or reference level of spontaneous and PHA and BCG -induced production of specific g-IFN at a density of IFN-gR1 on blood leucocytes not below reference. Sphere of application - phthisiology, pulmonology, immunology Product Description popup.authors Ільинська Ірина Федорівна Кадан Людмила Павлівна Коваль Наталія Григорівна Копосова Ірина Вікторовна Літвіненко Наталія Олександрівна Матвієнко Юлія Олександрівна Панасюкова Оксана Романівна Петішкіна Валерія Миколаївна Рева Олена Олександрівна Рекалова Олена Михайлівна Фірсова Ала Сергіївна Чернушенко Катерина Федорівна Ясир Світлана Григорівна popup.nrat_date 2020-04-02 Close