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Information × Registration Number 0214U000355, 0110U006647 , R & D reports Title Study of distinctive features of malignant cell differentiation popup.stage_title Head Sidorenko Svitlana Pavlivna, Registration Date 07-02-2014 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 In order to clarify and expand the expression profile of human B lymphocyte markers of differentiation, a study of the expression levels and post-translational modifications of key components of signal trunsduction cascades were performed. There signaling molecules are involved in the regulation of gene expression and may be potential markers of B cell differentiation. It was shown that the level of PKC II and SHIP-1 expression, and also the level of PKD2 expression and autophosphorylation can be used to clarify the stages of differentiation of normal and malignant B lymphocytes. The expression profile of IRF4, IRF8, Bcl-6, PU.1, SpiB and BLIMP1 transcription factors was clarified in normal and malignant B cells. It was shown that the level of S18- 2 protein expression is reduced during differentiation from pre-B cells into plasma cells. The relationship between the number of CD4 +, CD8 + and FOXP3 + lymphocytes in endometrial cancer microenvironment and biological characteristics of the tumors were defined. Product Description popup.authors Cидоренко Світлана Павлівна Білик Олена Олександрівна Брєєва Ольга Володимирівна Бучинська Любов Георгіївна Глущенко Наталя Миколаївна Гордієнко Інна Михайлівна Кашуба Олена Віталіївна Ковалевська Лариса Миколаївна Несіна Ірина Петрівна Романець Ольга Леонідівна Шабельник Мар'яна Юріївна Шлапацька Лариса Миколаївна Юрченко Марія Юріївна Юрченко Наталя Петрівна popup.nrat_date 2020-04-02 Close