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Registration Number

0214U000355, 0110U006647 , R & D reports

Title

Study of distinctive features of malignant cell differentiation

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Head

Sidorenko Svitlana Pavlivna,

Registration Date

07-02-2014

Organization

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

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In order to clarify and expand the expression profile of human B lymphocyte markers of differentiation, a study of the expression levels and post-translational modifications of key components of signal trunsduction cascades were performed. There signaling molecules are involved in the regulation of gene expression and may be potential markers of B cell differentiation. It was shown that the level of PKC II and SHIP-1 expression, and also the level of PKD2 expression and autophosphorylation can be used to clarify the stages of differentiation of normal and malignant B lymphocytes. The expression profile of IRF4, IRF8, Bcl-6, PU.1, SpiB and BLIMP1 transcription factors was clarified in normal and malignant B cells. It was shown that the level of S18- 2 protein expression is reduced during differentiation from pre-B cells into plasma cells. The relationship between the number of CD4 +, CD8 + and FOXP3 + lymphocytes in endometrial cancer microenvironment and biological characteristics of the tumors were defined.

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Cидоренко Світлана Павлівна
Білик Олена Олександрівна
Брєєва Ольга Володимирівна
Бучинська Любов Георгіївна
Глущенко Наталя Миколаївна
Гордієнко Інна Михайлівна
Кашуба Олена Віталіївна
Ковалевська Лариса Миколаївна
Несіна Ірина Петрівна
Романець Ольга Леонідівна
Шабельник Мар'яна Юріївна
Шлапацька Лариса Миколаївна
Юрченко Марія Юріївна
Юрченко Наталя Петрівна