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Information × Registration Number 0214U000393, 0112U002375 , R & D reports Title Purposeful design and synthesis of ligands to cellular targets that regulate the proliferation, differentiation and neoplastic cell transformation popup.stage_title Head Bozhkov A. , Papopnov B., Registration Date 26-02-2014 Organization Kharkov National University named after V.N. Karazin popup.description2 Object of research - focused design, synthesis and study of the interaction of ligands with low-molecular cell-targets, mainly from the ATP-binding sites of a large group of kinases that regulate the processes of proliferation, differentiation and cell transformation intractable. Purpose of the study - sphingozynе kinase, cyclin kinase (CDK), GSK3alfa and GSK3beta kinase, Aurora-kinase, VEGF, PDGF, FGF, FLT - receptor tyrosine kinase and several other kinases, low-molecular heterocyclic compounds that can act as inhibitors of ATP-called adhesion agent site of a large group of kinases that regulate the processes of proliferation, differentiation and cell transformation intractable. Research Methods - modern methods in molecular and systems biology, bioinformatics and chemicals. As part of this project to undertake comprehensive Design, synthesis and primary biological tests low kinase inhibitors cyclin dependent kinase (CDK), and GSK3beta GSK3alfa, Aurora-kinase, VEGF, PDGF, FGF, FLT - receptor tyrosine kinases, sphingozynе kinases and several other kinases, which together form a profile of activity that regulates the processes of proliferation, differentiation and neoplastic transformation of cells. First of all, they are designed as promising drugs for the treatment of several cancers, neurodegenerative diseases (Alzheimer's, Parkinson's) as NSAIDs for the treatment of autoimmune diseases, drugs for the treatment of acute renal failure and diabetes type two. Designed obtained and studied primarily multipurpose inhibitors of protein kinase activity with a defined profile and explore the qualitative changes in the profile of inhibition of structural modifications on the basis of one base molecule Product Description popup.authors Ічетовкін К. Львов С. Папонов Б. Сидоренко Д. popup.nrat_date 2020-04-02 Close