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Registration Number

0214U001069, 0111U002042 , R & D reports

Title

To develop new technologies of the synchronous chemo-radiotherapy of non-small-cell lung cancer, targeted of apoptosis induction.

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Head

Starenky V.P., Mitryaeva N.A.,

Registration Date

17-01-2014

Organization

State Grigoriev Radiological Institute of the National Academy of Medical Sciences of Ukraine

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Object of study: Efficacy of chemoradiation therapy in patients with non-small-cell lung cancer, CYFRA level 21-1 in serum of the patient, exchange of sphyngolipids in Guerin's carcinoma. Purpose of study: To improve efficiency of synchronous radiochemotherapy for non-small-cell lung cancer by developing new technologies using high-energy photon radiation and anticancer drugs with radiosensitizing effect based on the mechanisms of induction of chemoradiation effect on ceramide-mediated apoptosis in tumors. Methods and equipment: Clinical and instrumental , biochemical, electron microscopy, morphological, radionuclide, dosimetry.Theoretical and practical results: Informativity of CYFRA 21-1 tumor marker for monitoring the effectiveness of chemoradiotherapy was determined, the mechanisms of combined effects of high-energy photon radiation and etoposide on lipid accumulation of proapoptotic ceramide synthesis and increase in Guerin's carcinoma of sphyngozin against a background of activation of apoptosis was proven experimentally and confirmed by morphological studies. Novelty: For the first time, common mechanisms of action of high-energy photon radiation and anticancer drug etoposide in induction of apoptosis in tumor ceramide pathway was shown . Effectiveness of introduction: It can increase the objective response rate to 73.7 %, increase one-year survival to 70.0 %. Area of application - Radiotherapy and oncology.

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Білий О.
Бабенко Н.
Бакай Т.С.
Безугла В.С.
Гребіник Л.В.
Кондрашова О.І.
Куров О.М.
Лукашова О.П.
Мітряєва Н.А.
Насонова А.М.
Пасюга В.М.
Свинаренко А.В.
Сегеда Т.В.
Старенький В.П.
Тарасова О.М.
Узлєнкова Н.Є.

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2020-04-02