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0214U001075,
0113U000049
,
The comparative analysis of cytogenetic effects in cancer patients undergoing gamma- 60Co radiotherapy on "ROCUS" and megavolt photon therapy on linear accelerator
Maznyk N.A.,
17-01-2014
State Grigoriev Radiological Institute of the National Academy of Medical Sciences of Ukraine
Object of study - cytogenetic effects in cultured lymphocytes of cancer patients with different tumor localizations under the gamma-60Co-therapeutic radiation exposer. The aim - to assess the cytogenetic effects in lymphocytes of cancer patients following radiation treatment, depending on the energy of radiation dose and tumor localization, in order to improve biodosimetry in radiation therapy. Research methods and techniques - cytogenetic analysis of human blood cultured lymphocytes, statistical methods of data processing, microscope Biolam I, Axioskop, Micros MC 300X. Theoretical and practical results - it was shown the excess of chromosomal damage before treatment over spontaneous level in all groups of patients, regardless of tumor localization, and informativity of FPG- and Giemsa-staining to detect this excess was evaluated. The different pace of chromosomal and chromatid type aberrations accumulation in groups of patients with various tumor localizations was found. The monotonic increase of radiation-induced aberrations from beginning to end of treatment in patients with uterine cancer and lung cancer and less pronounced changes in these parameters in patients with head and neck tumors were demonstrated. These data are of importance for correctl assessing the impact of therapeutic irradiation on the chromosomal level. Novelty - within one study the quantitative yield and quality range of cytogenetic damage in lymphocytes of patients with uterine cancer, lung cancer and head and neck cancer before and during gamma-therapy 60Co were identified. Area of application - radiobiology, radiation therapy, biological dosimetry.
Білозор Н.В.
Кругова І.М.
Мазник Н.О.
Масіч О.В.
Пшенічна Н.Д.
Пшишевська Л.А.
Сипко Т.С.
Старенький В.П.
2020-04-02
Updated: 2025-12-08
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