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Information × Registration Number 0214U001393, 0113U002826 , R & D reports Title Mechanisms of caspase-dependendent death of leukemic cells in vitro caused by novel synthetic tubuline-affecting substances popup.stage_title Head Chekhun Vasyl Fedorovych, Registration Date 10-02-2014 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The cytotoxic, antiproliferative and apoptosis-inducing activities of synthesized triazol derivative of combretastatin (TDC) is practically the same as that of combretastatin (CA4). Although Jurkat/А4 cells turned out to be resistant to cytotoxic effects of CA4 and TDC, these compounds blocked cell cycle at G2/M phase and inhibited proliferation both of Jurkat and Jurkat/А4 cells. The apoptosis induction in TDC-treated Jurkat cells was accompanied with activation of initiator caspase-9 Product Description popup.authors Завелевич Михайло Петрович Куява Людмила Михайлівна Лупан Валентина Григорівна Фільченков Олексій Олексійович Чехун Василь Федорович popup.nrat_date 2020-04-02 Close