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Information × Registration Number 0214U001455, 0111U001483 , R & D reports Title Effect of histone deaсetylase inhibitors on the viability and longevity Drosophila melanogaster popup.stage_title Head Vaiserman Alexandr Mikhaylovich, Registration Date 18-02-2014 Organization State Institution "Institute of Gerontology AMS Ukraine" popup.description2 The past studies showed that the inhibitor of deacetylase-histones a sodium butyrate additted into the culture medium of Drosophila melanogaster during its development can prolong in concentration of 20 mg/dL can lead to the significant increase in the life span. In the presented work the insects contained in the standard conditions didn't have any effect of the drug on the expression of genes associated with aging (hsp70, sir2 and InR), as in the normal state of the body, as well as after exposure to stressors . In case of stress the expression of genes hsp70 and InR in the flies treated whith 20 mmol/L of sodium butyrate that showed the most pronounced effect of prolonged life, also did not differ from the corresponding values in the control. At the same time the expression of gene sir2 in the same insects after shock (starving) was significantly higher than in the control group. We suggest that the identified long-term effects of sodium butyrate during the stage of the development of Drosophila melanogaster are associated with the induction of epigenetic changes that persist for a long time. Product Description popup.authors Вайсерман О. М. Забуга О. Г. Коляда О. К. Орєхова Л. В. popup.nrat_date 2020-04-02 Close