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Information × Registration Number 0214U001458, 0111U001486 , R & D reports Title To study the influence of hypoxia on the rate of age-related changes at conditions of natural and irradiation-induced aging popup.stage_title Head Gorban Yevgen M., Доктор медичних наук Registration Date 18-02-2014 Organization State Institution "Institute of Gerontology AMS Ukraine" popup.description2 Interval hypoxic training (IHT) prior to exposure to ionizing radiation leads to the opposite reaction of the transcription factor HIF irradiated animals: in adult rats - significantly stepped up, in the old - depressed it. IHT exerted radioprotective effect on the system of lipid peroxidation in the tissues of the heart and liver of animals in both age groups. IHT had a positive effect on carbohydrate metabolism: in adult animals prevented the increase in glucose level, reduced glycosylated hemoglobin level in the blood in the early and late periods after irradiation; the old irradiated rats prevented IHT improving glycosylated hemoglobin and insulin resistance, decreased glucose level. IHT had a positive influencedt on lipid metabolism in adult and old irradiated animals. IHT positively affects the system of nitric oxide in the heart tissue of irradiated animals in both age groups, and some indicators in the aortic tissue of irradiated adult rats. IHT exerted radioprotective effects on locomotor activity of old irradiated animals. Product Description popup.authors Берестяна А.М. Горбань Є.М. Малаш Л.І. Омельченко Н.Ф. Под'яченко О.В. Проніна О.В. Топольнікова Н.В. Утко Н.О. Шкримбал О.М. popup.nrat_date 2020-04-02 Close