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Information × Registration Number 0214U001460, 0111U001488 , R & D reports Title Effect of early-life undernutrition on the rate of aging and mortality (experimental and demographic study) popup.stage_title Head Voitenko Vladimir Platonovich, Registration Date 18-02-2014 Organization State Institution "Institute of Gerontology AMS Ukraine" popup.description2 When growing larvae in nutrient medium containing carbohydrate and protein components in concentrations 50 % and 60 % compared with a standard feed mixture, a substantial increase was observed in the average and maximal life span of males. Lifespan extension of the insects can be the most essential provided nutrition restriction has been done, both at the larval stage and during imaginal period of ontogenesis of the flies. That is, matching of diets during development and throughout adult life insects has been found to be important. Nutrient restriction in the food substrate at the stage of development causes more significant changes in the transcriptional activity of Sir2 gene InR at larval versus adult stage. In the cohorts of people born in 1931-1935 years, the modeling of age-specific mortality in the range of 30 to 70 years using Gompertz function was done. No significant changes in the rate of aging of the human subjects have been found, whose early ontogenesis took place within 1932-1933-year period compared with the people born before or after the famine. No association between mortality from cardio-vascular diseases in the older age and starvation in early ontogeny has been established. Notably, the women born in 1930-1934 years living in the 1932-33-year famine areas had the higher mortality from cancer of the digestive and respiratory organs in the comparison with the women born in 1935-1939 years after the famine. In the regions of Ukraine being not exposed to famine such regularities were not observed. Product Description popup.authors Забуга О. Г. Коляда О. К. Мєхова Л.В. Писарук А.В. popup.nrat_date 2020-04-02 Close