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Information × Registration Number 0214U001516, 0111U007663 , R & D reports Title Peptides and proteins as targets of drugs, the synthesis of self-assembled molecular capsules - research and development of new technologies. popup.stage_title Head Komarov Igor, Registration Date 28-02-2014 Organization Taras Shevchenko Kiev university popup.description2 Synthesized building block containing fotoperemykach - molecular fragment capable of changing its conformation oborotno by light . Synthesized peptides based on it , and fluorinated analogs of the above peptides for their research in the membranes by 19F- NMR. Membranopronyknyy synthesized peptide , SAP, and its fluorinated analogues. Studied the formation of complexes of peptides with nanoparticles and penetration of the complexes into eukaryotic cells . The phenomenon of transport of nanoparticles into cells is mediated by the interaction of the peptide with SAP. Short cyclic peptides were synthesized containing six amino acid residues - known analogs of cyclic antimicrobial peptide c-(WFW). One or three amino acid residues in c-WFW substituted analogues of conformationally hindered amino acids in order to improve the selectivity of antimicrobial action . It is shown that analogues have the same antimicrobial activity as the prototype peptide c-(WFW). Analogs are characterized by the ability to effectively inhibit the growth of bacterial colonies - can destroy biofilms and biofilm at sufficiently low concentrations. We found that the antibiotic peptide analogues nature of gramicidin S fotoperemykachem composed of polypeptide chains change their biological activity oborotno by light . Product Description popup.authors Комаров І. Коновець А. Радченко Д. Рачков О. Рожков В. Шиванюк О. popup.nrat_date 2020-04-02 Close