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Information × Registration Number 0214U001545, 0112U004235 , R & D reports Title Polifunkcional'nye and multicentral cellular complexes with the incapsulated ion of metal are prekursory of topological medications, diagnostic and pharmaceutical preparations popup.stage_title Head Volkov Sergei Vasiljevich, Registration Date 06-03-2014 Organization National Academy of Scienіses of Ukraine, Council of Productive Forces Studies of Ukraine popup.description2 Report PDR: str., figure , table , sources . The project was aimed at creating new types of biologically active substances from makrobitsyklichnyh Tris dyoksymativ with encapsulated metal ion as a synthetic platform for supramolecular design of bioactive compounds, the synthesis of compounds capable of topological inhibition of vital enzymes. Try apical and edge-functionalized polytopic klatrohelaty and bis-klatrohelaty iron and cobalt (II), containing farmakoforni groups for screening and binding study of transport proteins, as well as new klatrohelatni complexes containing pirazolni fragments in macrocyclic skeleton. Synthesized a new type of structural klatrohelativ containing pirazoloksymni rib fragments and lacunary systems - pirazoloksymboraty iron, cobalt, manganese, and zinc. New pirazoloksymni klatrohelaty are in high spin state , which makes them promising as paramagnetic probes for structural studies of biological objects. Established that klatrohelaty of halohenfuranovymy substituents are promising skaffoldamy to obtain functionally substituted klatrohelativ and create libraries of compounds for biological activity studies . Product Description popup.authors Варзацький О. А. Денисенко І.М. Третякова І.М. Федосова Н.М. Черній В. Я. Чорненька Н.В. popup.nrat_date 2020-04-02 Close