Search academic texts

Information × Registration Number 0214U001822, 0110U004753 , R & D reports Title Systemic and molecular-genetic investigations jf mechanisms hypertrophy and heart failure development popup.stage_title Head Moybenko Olexij Olexijovych, Registration Date 24-07-2014 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 It is first shown that during heart remodeling the expression of genes encoding MMP-2 and MMP-15 as well as gene of matrix metalloproteinase inhibitors (TIMP-1 та TIMP-2) expression is increased. The drugs of Quercetin prevent myocardial fibrosis and normalize the expression of genes mentioned above. The changes in hemodynamic parameters and pathological changes in the histology of the heart cells in SHR are also shown firstly. These changes were accompanied with changes in the expression of genes encoding proteasome subunits and transcription factors SREBF-1 and SREBF-2. Product Description popup.authors А.Г.Портніченко А.М.Шиш А.С.Жуковська В.Є. Досенко В.В.Клещевников В.Л. Гур'янова В.С.Нагібін Г.В. Портніченко Д.О. Строй Д.О.Пашевін Л.В.Тумановська О.В. Сваричевський О.О. Лісовий О.О.Мойбенко О.С.Панасюк Р.А. Ровенець Р.Б.Струтинський С.Б. Французова С.В.Гончаров Т.Ю.Лапікова-Бригінська popup.nrat_date 2020-04-02 Close