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Information × Registration Number 0214U002201, 0109U001590 , R & D reports Title Study of the mechanisms of regulation and interactions of the protein components of blood coagulation and fibrinolytic systems with blood cells involved in haemostasis. popup.stage_title Head Lugovskoy Eduard Vitaljevich, Registration Date 24-01-2014 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 The localization of epitope and the site of lateral association of protofibrils were determined using monoclonal antibody (monAB) that was obtained; antibody able to inhibit fibrin polymerization was also produced. Immunoassay test for the prognosis of early risk of thrombotic events based on monAB I-5В and I-6В was manufactured. The computer model of three-dimensional orientation of ?С-regions of fibrinogen, fibrin desA nad desAB was proposed; the role of ?С-regions in stabilization of fibrinogen structure and intermolecular interactions of fibrin was determined. The technique of limited proteolysis of fibrinogen by fibrinogenase from the venom of Echis multisquamatis was developed. It was shown that meizothrombin promotes platelets involving in thrombus formation, meanwhile prethrombin-1 inhibits blood coagulation by inhibition of secondary platelet aggregation. Product Description popup.authors Є.М. Макогоненко І.М. Колєснікова А.В. Петік А.С. Дубовецький В.А. Соколовський В.О. Чернишенко Г.І. Горідько Г.К. Гоголінська Г.К.Березницький Д.С. Корольова К.С. Андріанова Л.В. Пирогова Л.М. Литвинова Л.П. Урвант М. О. Пидюра Н.Е. Луговська Н.С. Сторожилова О.В. Горницька О.П. Костюченко О.Ю. Сломінський С.І. Андріанов Т.А. Позняк Т.В. Горошнікова Т.М. Платонова Т.М. Чернишенко popup.nrat_date 2020-04-02 Close