Search academic texts

Information × Registration Number 0214U002202, 0112U004254 , R & D reports Title Design and synthesis of nitrogen containing bisphosphonates of new generation, investigation of their synergism with vitamin D3 in treatment of bone tissue diseases. popup.stage_title Head Komisarenko Serhiy, Доктор біологічних наук Registration Date 24-01-2014 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 A preparative methods and synthesis of 4 -R- 1 ,3- dyalkyl pyrazole and pirazole-containing hydroxy bisphosphonates were carried out. It was demonstrated that the synthesized nitrogen-containing bisphosphonates (pirazole-containing analogues), like comparison drugs - MBFK and alendronate, with the different efficacy decreased demineralization process (resorption) and enhanced mineral metabolism in bone tissue of rats with the alimentary form of osteoporosis that was assessed by marker indices in blood and bone. It was found synergistic effects of new nitrogen-containing bisphosphonates and vitamin D3 on the regulation of osteoporosis-associated structural and functional impairments in the bone and immune system. Product Description popup.authors І.О. Шиманський Л.І. Апуховська М.М. Великий О.О.Лісаковська popup.nrat_date 2020-04-02 Close