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Information × Registration Number 0214U002303, 0112U002410 , R & D reports Title The role of nitric oxide, oxidative stress and polymorphism of the NOS3 gene in development mechanism of unfavourable results of Chornobyl catastrophe in children at chronic income of 137Cs into organism popup.stage_title Head Stepanova Yevgeniya Ivanovna., Доктор медичних наук Registration Date 28-01-2014 Organization Research Centre for Radiation Medicine popup.description2 The object of study : children - residents of contaminated territories (RCT). Purpose - to determine the activity of free - radical processes , system state, pro-and anti-oxidants , vasoactive pool level of nitric oxide in terms of its ultimate metabolites in serum and endothelial reactivity in children with different contents incorporated 137Cs and the control group . Research Methods : Clinical , laboratory , instrumental , statistics . Results and novelty . in children - residents RСT with 137Cs content from 269 to 6253 Bq in the body in the study of endothelial reactivity thermography method with occlusion test showed signs of endothelial dysfunction. In determining the content of these children have NO metabolites in blood serum identified significant decrease in nitrite - (6,43 ± 0,35) pmol/l. Noted the adequacy of compensatory antioxidant capacity of the system, a fact that is confirmed by the activation of the main intracellular antioxidant - catalase in the absence of significant changes in the final product PAUL - MDA. The study of cardio - vascular system shows a decline in children of primary functional capacity of the myocardium due to indicators such as the сardiac out put determines the hypokinetic state , as well as an increase of the total peripheral resistance to maintain blood pressure. The most common ECG - phenomena were repolyarized abnormalities final link segment S - T, slowing conduction by right bundle branch block and incomplete blockade of conduction of right bundle branch block , reducing the interval P - Q, early repolarization pattern, migration source automatism. In them there is a small part of the central mechanisms of heart rhythm control, which is not accompanied by increased activity of an independent circuit and does not provide a sufficient body's ability to achieve adequate adaptation without breaking the vegetative homeostasis. The vegetation is dominated by the homeostasis amphotonia (60.39%) in the initial vegetative tone , leading nervous channel regulation (55.45% ) reduction of adaptation - coping mechanisms (43.57%); asimpatikotonichny option autonomic reactivity (12,88%) i insufficient connection sympathetic nervous system in modeling long-term functional load ( asimpatikotonichny option - 30.69 % ; sympathetic - asthenic - 22.77 % and giperdiastolichny option - 5.94 %). Where there is evidence of endothelial dysfunction observed trend of more expressive changes of cardio - vascular system. All this indicates the presence of the children - residents RCT cardiovascular maladjustment syndrome . The children - residents RCT , there was a decrease in the functional activity of neutrophils and some changes of immunological parameters with the development of allergic and infectious syndromes secondary immune deficiency. Product Description popup.authors Вдовенко Віталій Юрійович Гриценко Тетяна Володимирівна Колпаков Ігор Евгенович Кондрашова Валентина Григорівна Леонович Олена Семенівна Литвинець Оксана Михалівна Скваська Олена Олександрівна popup.nrat_date 2020-04-02 Close