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Information × Registration Number 0214U002570, 0113U003683 , R & D reports Title Using genetic and pharmacological inhibitors of protein kinase C, as agents for the treatment of chronic pain of various genesis, with minimal side effects popup.stage_title Head Voitenko Nana Volodymyrivna, Registration Date 16-01-2014 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 We shown that complete Freund's adjuvant (CFA)-induced peripheral inflammation induces a time-dependent GluR2 phosphorylation at Ser880 and subsequent disruption of GluR2 binding to its synaptic protein, resulting in a switch of GluR2-containing AMPARs to GluR2-lacking AMPARs and an increase of AMPAR Ca2+ permeability at the synapses in dorsal horn neurons. Phosphorylation GluR2 subunit and its internalization is dependent on the activation of protein kinase C ? in the dorsal horn neurons. Product Description popup.authors Білан Павло Володимирович Войтенко Нана Володимирівна Вятченко-Карпинский В'ячеслав Юрійович Гончаренко Юлія Володимирівна Копач Ольга Володимирівна Хомула Євген Валерійович Черкас Володимир Петрович popup.nrat_date 2020-04-02 Close