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Information × Registration Number 0214U002575, 0110U004745 , R & D reports Title Investigation of the molecular mechanisms of the course of Alzheimer's disease at the molecular and cellular levels and their pharmacological correction popup.stage_title Head Kostyuk Olena Platonivna ( 2010-2012), Skryl Vyacheslav Mikhailovich (2012-2014), Registration Date 16-01-2014 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Using the methods of two-wave calcimetry and fluorescent dye fura-2AM, the effect of memantine on the processes of synaptic plasticity of hippocampal neurons in control and on the cells, which were incubated with beta 1-42-amyloid within 24 hours (cellular model of Alzheimer's disease), compared with the corresponding values in control. It was found that memantine induced an increase in the amplitude of calcium transients and did not affect the basal level of calcium in the cells of the hippocampus. Product Description popup.authors Кравенська Євгенія Вікторівна Лук"янець Олена Олександрівна Чоповська Віта Вікторівна Шкриль В"ячеслав Михайлович Яворська Олена Миколаївна popup.nrat_date 2020-04-02 Close