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Information × Registration Number 0214U002576, 0110U004755 , R & D reports Title Systemic and molecular mechanisms of cardiac remodeling and biotechnological methods of cardioprotection: regulation of gene expression encoding microRNA, factors of natriuretic protein system and proteins involved in cardiac failure progression popup.stage_title Head Moybenko Olexij Olexijovych, Registration Date 16-01-2014 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 The genetic screening of 48 genes at heart remodeling of different genesis was done. It was established that isoproterenol-induced damaged of the heart leads to changes in expression of the next genes: Agtr1a, Col1a1, Col3a1, Ptgs2, Timp2. Myocardial infarction reproducing had decreased the expression of 17-n genes and 7 of them are included in cardiac remodeling process: Ace2, Atp2a2, Col3a1, Mef2c, Mmp15, Mmp2, Timp2. The profile of gene expression was very different at coronarigenic and noncoronarigenic damage of the heart. The expression of the most of genes was decreased at coronarigenic damage comparing to isoproterenol model. Product Description popup.authors Гончаров С.В. Гур'янова Вероніка Леонідівна Досенко Віктор Євгенович Мойбенко Олексій Олексійович Пашевін Д.О. Портніченко Г.В. Строй Дмитро Олександрович Тумановська Леся Володимирівна popup.nrat_date 2020-04-02 Close