Search academic texts

Information × Registration Number 0214U003268, 0109U000023 , R & D reports Title Scientific substantiation of hygienic regulations of the limiting maintenance of medical products in objects of environment and working of quantitative methods of their determination in the air popup.stage_title Head Kuzminov B., Registration Date 28-01-2014 Organization Danylo Halytsky Lviv National Medical University popup.description2 A scientific substantiation of hygienic regulations of the limiting maintenance of bismuth citrate, L-lysine aescinat, procaine hydrochloride, diphenhydramine hydrochloride, cyanocobalamin, tris-[N-(2,3-dimethylphenyl) antranilat] aluminum hydrate (antral), ethyl-2-bromo-3-methyl butanoat in the air of the working area and developed quantitative methods for their determination. Toxicological studies have established that bismuth citrate can excite the central nervous system, reduce the number of red blood cells and hemoglobin levels, cause a pronounced irritating to mucous membranes, has a very pronounced cumulative activity. L-lysine aescinat has a negative effect on the central nervous system and the urinary organs, has a weak locally irritant effect on the skin and pronounced damaging effect on mucous membranes. Prolonged contact with the substance is likely to develop autoimmune processes. Procaine hydrochloride - blocking central nervous system, causing poor locally irritating effect on the mucous membranes reveals a pronounced mid irritating , may cause alerohennu restructuring in the body (according to the literature). Diphenhydramine hydrochloride - blocks H1 receptors, inhibits the work of the central nervous system, has a weak locally irritant effect on the skin and severe damaging effects on the mucous membranes, can lead to the formation of allergenic reactions. Cyanocobalamin - activates the clotting effect on the CNS, the functional state of the liver. In the event of skin-resorptive causes toxic and weak locally irritating effect on the mucous membranes-slightly irritating. Has low allergenic activity. Antral affect the functional state of the liver. Do not exhibit skin-resorptive and locally irritant effect on skin and mucous membranes. Allergenic activity is not detected. Ethyl-2-bromo-3-methyl butanoat affects the central nervous system, has a skin-resorptive effect; locally irritating effect on the skin available on mucous membranes - the low. Allergenic activity is not detected. Reasonable standards of acceptable content of these substances in the air of the working area showing their class nature of the hazard and exposure controls: bismuth citrate - 1.0 mg/m3 MAK, class II, marked "+"; L-lysine aescinat - MAC 2.0 mg/m3, III class mark "+"; procaine hydrochloride - MAK 0.5 mg/m3, class II, allergen, diphenhydramine hydrochloride - ASLI 0.2 mg/m3, marked "+"; cyanocobalamin - MAK 0.05 mg/m3, I class mark "+"; antral - ASLI 1.0 mg/m3, ethyl 2-bromo-3-methyl butanoat - MAK 5.0 mg/m3, II class. Developed, approved and certified metrological methods of measurement ( MVI ) concentrations of the above compounds in the air of working zone, "MVI mass concentration of bismuth citric acid in the air of the working area photometric method" (MVI № 081/12-0250-05 of 28.11.2005); "MVI mass concentration of L-lysine aescinat in the air of the working area photometric method" (MVI № 081/12-0412-07 of 22.02.2007); "MVI mass concentration of novocaine (procaine hydrochloride) in the air of the working area photometric method" (MVI № 081/12-0602-09 of 23.02.2009), "MVI mass concentration of diphenhydramine (diphenhydramine hydrochloride) in the air of the working area photometric method" (MVI № 081/12-0601-09 of 23.02.2009), "MVI mass concentration of cyanocobalamin in the air of the working area spectrophotometric method" (MVI № 081/12-0603-09 of 23.02.2009), "MVI mass concentration of tris -[n-(2,3 - dimethylphenyl) antranilat ] aluminum hydrate (antral) in the air of the working area photometric method" (MVI № 081/12-0831-12 of 25.12.2012), "MVI mass concentration of ethyl-2-bromo-3-methyl butanoat in the air of the working area chromatographic method" (MVI № 081/12-0832-12 of 25.12.2012). Product Description popup.authors Альохіна Тетяна Анатоліївна Брицька Валентина Савеліївна Галушка Олександр Іванович Грушка Оксана Іванівна Де Агіар Даніель Ауріс Марія Зазуляк Тетяна Степанівна Кузьмінов Борис Павлович Кузьмінов Олександр Борисович Паздерська Ірина Богданівна Перейма Іван васильович Туркіна Віра Артурівна Шевчук Люба Павлівна popup.nrat_date 2020-04-02 Close