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Information × Registration Number 0214U003424, 0111U002011 , R & D reports Title Investigation of new domestic anti-HIV drugs with new mechanisms of action in models of mono and mixed infections" for the year 2011-2013 popup.stage_title Head Rybalko S.L., Registration Date 31-01-2014 Organization The L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases AMS of Ukraine popup.description2 The main purpose of this work was to study the antiviral activity of domestic drugs with different mechanisms of action in models of mono-and mixed HIV + opportunistic viral infection. The work was vykorstani slidyuchymy drugs with mechanisms of action : reverse transcriptase inhibitors - nucleoside , non-nucleoside drugs and flavonoid proteflazidum , amantadine derivatives - blocker tool cellular protein matriksnoho r17 ; lektyvir - a drug that interacts with receptors sialospecific glycopeptides gp120, disrupting the interaction of the virus with the cell at initial stages mimikryny acting on the principle of " mimotopiv " block viral replication and antypuhlynni drugs. Obtained and characterized by mixed infection: HIV- Herpes , HIV- hepatitis C, HIV + adenovirus , HIV + EBV , HIV-positive influenza. On models mono -HIV , HSV, HCV inhibitors discovered active HIV replication and investigated the chemical nature of domestic agents Product Description popup.authors Н. Іванська О. Васильченко С. Григор'єва С. Дядюн С. Рибалко Т.Ю. Трохимчук popup.nrat_date 2020-04-02 Close