Search academic texts

Information × Registration Number 0214U003475, 0111U004731 , R & D reports Title Theoretical and experimental justification for the development of nanocomposite coatings based on biopolymers and antimicrobial agents for medical implants popup.stage_title Head Kazmirchuk Victor Vladimirovich, Registration Date 04-02-2014 Organization The Mechnikov Research Institute of microbiology and immunology at Kharciv popup.description2 Object of study - a nanocomposite material for medical purposes ( in the form of powders and coatings on titanium substrates ) that is based on the inclusion of hydroxyapatite bioactive molecules ( chitosan) and drugs ( decamethoxin , ethonium ) . Purpose - to study the antimicrobial properties of nanocomposite coatings with HA addition of silver ions , biomolecules ( chitosan, collagen) , drugs ( decamethoxin , ethonium ) . Research Methods : physico - chemical, technological , microbiological , morphological, mathematical - statistical . The production technology of composite coatings on metal substrates , based on HA and chitosan with silver by addition of drugs. The morphology , phase composition , the influence of the organic components of drugs on the structure of the coatings . Determine the minimum inhibitory concentration of chitosan with different molecular weights on a number of strains of microorganisms and the effect of temperature on the antibacterial properties of chitosan . Investigated the antimicrobial properties of composite materials, including involving decamethoxin on the most common causative agent of inflammatory processes. The effect of antimicrobial agents ( chitosan , silver) on the adhesive properties of microorganisms. The influence of metal ions on the antimicrobial activity of chitosan. Studied the rate of development of microbial resistance towards chitosan. The analysis of acute toxicity of coating materials . Product Description popup.authors Волянська Н.О. Казмірчук В.В. Поволокіна І.В. Радченко О.О. Чумаченко О.О. Шульга Н.М. Юдін І.П popup.nrat_date 2020-04-02 Close