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Information × Registration Number 0214U003897, 0111U004772 , R & D reports Title Investigation of bone marrow and adipose tissue stromal cells directed differentiation and the development the technology for usage of differentiated autologous cells for the treatment of various origin deseases popup.stage_title Head Khvysuk A.N., Registration Date 11-03-2014 Organization Kharkiv Post-Graduate Medical Institute popup.description2 The object of study - stromal cells of the bone marrow and adipose tissue. Purpose - to study the induction of directional differentiation of bone marrow stromal cells and adipose tissue and development of technologies of differentiated autologous cells for the treatment of various origins. Research Methods - histological, planimetric, cultural, cytological, clinical and statistical. A: study of the effect of transplantation of mesenchymal stem cells in the course of the simulated ischemic stroke in rats; development of methods of supravital staining stromal stem cells for long-term tracking of cells, the study of the influence of gene mutations in Lamin differentiation of bone marrow stromal cells and adipose tissue, to study the impact of term culturing of stromal cells to the number of chromosomal aberrations, to study the effect of the use of bone marrow stromal cells and fibroblasts in skin treatment burn wounds. Established: the introduction of bone marrow stromal cells in the treatment of experimental ischemia in rats stimulated recovery processes, mutations in the gene Lamin A / C significantly affect the process and the level of osteogenic differentiation adipotsitarnoho and stromal cells of adipose tissue, with long-term cultured bone marrow stromal cells in rats increased the number of aberrant chromosomes, the use of autologous bone marrow stromal cells, fibroblasts and skin conditioned media on them effectively in the treatment of venous ulcers and burns. Product Description popup.authors А.С. Забірник О.А. Омельченко С.В. Малишкіна С.Г. Панібратцева popup.nrat_date 2020-04-02 Close