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Information × Registration Number 0214U003956, 0111U003686 , R & D reports Title Investigation of adverse actions of medicines and development of prophylactic measures for patients with spread dermatoses popup.stage_title Head Soloshenko Elvira Mykolayivna, Registration Date 20-03-2014 Organization Ukranian research institute of dermatology and venerology popup.description2 Object of study: patients with common dermatoses complicated by allergy, common dermatoses patients without complicated, apparently healthy persons. Purpose - to increase the effectiveness of treatment and prevention of common dermatoses in patients with complicated or allergy based on a study in which individual risk factors side effects of drugs and research adaptive state of immune homeostasis and hematological parameters. Methods: epidemiological, clinical, biochemical, immunological, genetic, bacteriological, statistics. Found that in statistical reports are not provided data on cutaneous manifestation of the side effects of medicines associated with common dermatoses. Among the 195 surveyed were recorded more often in patients with cutaneous manifestations of drug disease (23.6 %). Allergic reactions to medicines is virtually all patients with common dermatoses - among patients with eczema in 70.8 % of patients , including patients toksidermii food - in 22.7 % of patients with psoriasis - in 44.4 % of patients with atopic dermatitis and allergic - in 72.0 % of patients with other dermatoses - 60.8 %. A characteristic feature of the flow is common dermatoses polisensibilization not only drugs but also on products (40 % of the patients ), household (19.5 %) and pollen allergens (12.8 %). Revealed that there are inherent risks, whose role in the etiology of the disease is increasing against the backdrop of complicated allergic history. Patients with complicated common dermatoses or allergy revealed more severe disorders of adaptation mechanisms of immune homeostasis integral hematological indices barrier and transport functions of cells , skin colonization compared with patients without common dermatoses complicated history. The correlation between the polymorphism 1258G/A gene SPINK5 and the likelihood of common dermatoses with complicated or allergy. Found that genotype GG 1258G/A is a risk factor for atopic dermatitis and allergic with a complicated history. AA genotype 1258G/A is a risk factor for morbidity medicinal disease . Developed a method for treating and preventing relapse common dermatoses with complicated or allergy. Product Description popup.authors Іванова Ніна Миколаївна Білозоров Олексій Павлович Васильєва Олена Сергіївна Волкославська Валентина Миколаївна Гутнєв Олександр Леонідович Джораєва Світлана Кар'ягдиївна Земляна Тетяна Вікторівна Зюбан Ірина Володимирівна Кондакова Ганна Костянтинівна Кутасевич Яніна Францівна Мілютіна Олена Йосипівна П'ятикоп Інна Олександрівна Пєєва Людмила Іванівна Семко Галина Олександрівна Солошенко Ельвіра Миколаївна Стулій Ольга Миколаївна Цимбал Вікторія Миколаївна Частій Тетяна Володимирівна Шевченко Зоя Михайлівна Ярмак Тетяна Павлівна popup.nrat_date 2020-04-02 Close