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Information × Registration Number 0214U005270, 0114U005351 , R & D reports Title Aplication of aminophosphonates in synthesis of biologically active compounds popup.stage_title Head Kukhar V.P., Registration Date 16-12-2014 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 Synthesis of fluorinated aminophosphonates using boronic variant of Mannich reaction has been developed. The advantages of the described method are the availability of reagents, environmentally friendly synthesis, high diastereoselectivity, good yield and short reaction time. The primary biological research of difluoromethylphosphonates on tetrazamacrocyclic platform has been carried out. The results of the investigations indicate the prospects of further study of phosphonate-functionalized polyazamacrocyclic compounds as potential inhibitors of protein tyrosine phosphatases. Product Description popup.authors В. Д. Романенко Л. А. Кононець О. Є. Сорочинський popup.nrat_date 2020-04-02 Close