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Information × Registration Number 0214U005301, 0111U010127 , R & D reports Title To study the patogenetic mechanisms of immunological disorders caused by violation of gamma interferon production and reception in patients with destructive pulmonary tuberculosis popup.stage_title Head Rekalova Elena Myhaylovna, Registration Date 16-01-2015 Organization SO "National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine" popup.description2 Object - 70 patients with destructive pulmonary tuberculosis and 30 healthy subjects. Aim - to work out of technology use drugs interferon and of inducers in patients with destructive pulmonary tuberculosis by examining variations in the interferon system disorders based on data analysis of specific and nonspecific immune resistance. Methods - clinical, immunological, statistical. Were established, that mononuclear immune deficiency (MIN) occurs in almost all patients on the DTBL (99%) and in 73 % patients these changes were profound (third degree) and were combined with a combination of depressions of T-, B- cells and monocytes (57 %). Developed by: technology identify additional criteria mononuclear immune deficiency on indicators system g-IFN and technology identify additional criteria for assessing the functional status of circulating phagocytes. Highlighted four main variants of changes in g-IFN, that accompanied by inhibition of effectors cell function of the immune defense. Principles were grounded of rational immunotherapy using drugs g-IFN and its inducers and were offered its scheme. Developed method for immunotherapy in patients with pulmonary tuberculosis and determining the indications for the use of bacterial peptidoglycan Blastomunil to correct the system g-IFN. Developed method for the treatment of patients with pulmonary tuberculosis, which helps normalize the system of g-IFN and immune system as a whole, which increases the effectiveness of treatment by reducing in 1,9 times the timing resolution of infiltrative changes in the lungs, increasing 2,2 times the percentage of patients, in which disappeared the cavity in the lungs and were reduced in 1,3 times periods of stay of patients in hospital. Sphere of application - phthisiology, pulmonology, immunology Product Description popup.authors Ільинська Ірина Федорівна Зубрійчук Оксана Миколаївна Кадан Людмила Павлівна Коваль наталія Григорівна Копосова Ірина Вікторовна Литвиненко Наталія Олександрівна Матвієнко Юлія Олександрівна Панасюкова Оксана Романівна Петішкіна Валерія Миколаївна Рева Олена Олександрівна Рекалова Олена Михайлівна Сінгаєвський Мирослав Богдановия Фірсова Ала Сергіївна Чернушенко Катерина Федорівна Ясир Світлана Григорівна popup.nrat_date 2020-04-02 Close