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Information × Registration Number 0214U005409, 0110U004714 , R & D reports Title Investigation of molecular and genetic mechanisms of carbohydrate and lipid metabolism modulation, and prevention of metabolic syndrome under high altitude hypoxia popup.stage_title Head Portnychenko Alla Georgijivna, Registration Date 26-12-2014 Organization International Center Astronomical, Medical and Ecological Research popup.description2 Results of research for the first time characterize the molecular and genetic mechanisms of metabolic regulation and correction of pathological changes in the high altitude hypoxia and other hypoxic influences. The study was performed in 134 volunteers aged 40-75 years, the inhabitants of the plains (Kyiv) and middle altitude (Terskol, Elbrus region), including 55 patients with metabolic syndrome and diabetes, as well as in rats with modeling of metabolic disorders . It was established that acclimatization to hypoxia improves carbohydrate metabolism, optimizes lipoprotein metabolism and metabolic response of remodeled heart and lungs on hypoxic preconditioning. The role of protein regulators of IGF-1, HSP60 and leptin, lipoprotein receptor and cofactor ApoER2 and paraoxonase-1, transcription factors HIF-1, HIF-3, p53 in protective metabolic effects was found. Application of hypoxia in metabolic syndrome and aging reduced dyslipidemia and normalized glycemic profile. Three regimen of hypoxic influence, which demonstrated high clinical efficiency, were developed. The approaches for gene and combined therapy of metabolic syndrome were substantiated. Product Description popup.authors Бакуновський Олександр Миколайович Василенко Марина Ігорівна Лапікова-Бригінська Тетяна Юріївна Портніченко Володимир Ілліч Сидоренко Алла Михайлівна popup.nrat_date 2020-04-02 Close