Search academic texts

Information × Registration Number 0214U005435, 0110U005770 , R & D reports Title Development of biotherapy drugs (biomolecules) by RNA-based technologies to correct molecular disorders found in tumor cells popup.stage_title Head Chekhun Vasyl Fedorovych, Registration Date 29-12-2014 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 We studied changes in the expression profile of several miRNAs, methylation status of promoter regions of genes, involved in iron metabolism and sensitivity of breast cancer cells to anticancer drugs after 5-azacytidine treatment. We showed that cultivation with 5-azacytidine caused FTH1 and TRF1 promoter demethylation in breast cancer cells and changed expression levels of certain miRNAs, such as mir-10b, mir-200b, mir-34a and mir-133, through loss of CpG-islands methylation in the promoter of correspondent genes. These changes in epigenetic gene regulation of iron metabolism significantly contributed to increase of sensitivity of breast cancer cells to cisplatin and doxorubicin. Product Description popup.authors Борікун Тетяна Вікторівна Кунська Любов Миколаївна Лук'янова Наталія Юріївна Мельник Наталія Миколаївна Чехун Василь Федорович Чехун Святослав Васильович popup.nrat_date 2020-04-02 Close