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Information × Registration Number 0214U005451, 0110U006128 , R & D reports Title Development of fundamentals methods rof cell therapy of heart pathologies popup.stage_title Head Lyubov L. Lukash, Доктор біологічних наук Registration Date 30-12-2014 Organization Institute of Molecular Biology and Genetics popup.description2 Using conditional knockout animals we examined the expression of genes involved in the canonical Wnt-signalling (TSF-4, Axin2, b-catenin) and genes under the control of this signaling pathway (cFos, Cyclin D1, cMyc, Sh43) myocardium in animals ages 1, 3, 6 and 9 months, provided embryonic cardiac- deletion allele of one gene b-catenin. We observed inhibition of canonical Wnt-signalling in all age groups studied (1, 3, 6 and 9 months). Analysis of genes under the control of the canonical Wnt-way revealed changes in their expression level in tissues of animals with cardiac- b-catenin deficiency. We discuss the importance of the proper functioning of the canonical Wnt-signalling for the growth and development of adult cardiac infarction Product Description popup.authors Мацевич Лариса Леонідівна Півень О.О. popup.nrat_date 2020-04-02 Close