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Information × Registration Number 0214U005454, 0110U005758 , R & D reports Title Cationic antimicrobial peptides: expression patterns in melanoma cells in vitro and in vivo popup.stage_title Head Роgrebnoy Petro Vasylievich, Registration Date 30-12-2014 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The possibilities of use of recombinant beta-defensins as anticancer agents were studied in vivo with the use of melanoma В16 as experimental model. We have tested 3 methods: 1) preincubation of transplanted melanoma В16 with recombinant defensins; 2) topical application of preparation of recombinant peptide in the region of primary tumor development ; 3) intratumoral injection of recombinant peptide preparation . Intratumoral injection of recombinant beta-defensin in experimental melanoma resulted in positive antimetastatic effect in combination with systemic administration of vitamin D3 to experimental animals. This effect could be explained by immunomodulating properties of beta-defensin-2 and positive regulation of this defensin in the in lung tissue of mice upon the action of vitamin D3. Product Description popup.authors Геращенко Ольга Леонідівна Глушко Наталія Віталіївна Журавель Олена Валентинівна Солдаткіна Марія Олександрівна popup.nrat_date 2020-04-02 Close