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Information × Registration Number 0214U005679, 0112U005097 , R & D reports Title 3-Substituted dihidrobenzodiazepines - new generation of promising analgesics and anxiolytics popup.stage_title Head Andronati S.A., Registration Date 11-02-2014 Organization A.V.Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 A series of 3-alkoxy-and 3-arylamino-1,2-dihydro-3H-1,4-benzodiazepine-2-ones, which have a significant analgesic activity with values from ED50 to 0.007 from 6,800 mg/kg (diclofenac sodium, ED50 = 10,00 ± 1,80 mg/kg). It has been found the compound - leader (7-bromo-5-(2'-chloro)phenyl-3-propoxy-1,2-dihydro-3H-1,4-benzodiazepine-2-one), prospective for the preclinical study, which has a high analgesic (ED50 = 0,03 ± 0,007 mg/ kg) and a significant anxiolytic activities with low toxicity (LD50> 1000 mg/kg). For this compound have been developed laboratory regulations for the substance obtaining. Product Description popup.authors В.И. Павловский Е. Вороненко Е. Семенишина Е. Халимова И. Ушаков Н. Ильюшко О.Н. Дехтяренко Т. Кабанова Т. Юрпалова Т.Л. Карасева Я. Кривенко popup.nrat_date 2020-04-02 Close