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Information × Registration Number 0214U005905, 0114U000716 , R & D reports Title Preparation of stable tumor cell lines expressing phenotypic and molecular features of cancer stem cells (CSCs), to develop and monitor the effectiveness of new anticancer drugs: evaluation of mTOR/S6K-dependent signaling pathways popup.stage_title Head Filonenko Valeriy Viktorovitch, Доктор біологічних наук Registration Date 26-12-2014 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 An adenocarcinoma cell subline of human breast cancer with stable overexpression adapter protein Rukl / CIN85 and held their characteristics. The level of phosphorylation of key components of the PI3K / mTOR / S6K-dependent signaling pathway (kinase AKT and S6K, ribosomal protein S6) analyzed the correlation between expression Rukl / CIN85 and activation of the signaling pathway. For antibodies against components of the mTOR protein complexes C1 and C2 proteins Raptor and Rictor created corresponding recombinant design, cloned and recombinant peptides obtained corresponding to C and N fragments indicated proteins. Product Description popup.authors Маланчук Оксана Миколаївна popup.nrat_date 2020-04-02 Close