Search academic texts

Information × Registration Number 0214U005906, 0110U006121 , R & D reports Title Generation and characterization of moloclonal antibodies to oncogenic, mutant forms of fibroblast growth factor receptor (FGFR3 ) for diagnostics and immunotherapy of tumors popup.stage_title Head Filonenko Valeriy Viktorovitch, Доктор біологічних наук Registration Date 26-12-2014 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 Monoclonal antibodies against surface receptors that induce the activity of relevant signaling systems are promising targets in the treatment and diagnosis of a number of severe pathologies person. With the use of hybridoma technology and using as antigen cells expressing mutant forms of FGFR3, were obtained monoclonal antibodies C2 that recognize a mutant form of the receptor and wild-type form. Compared with antibodies obtained against the recombinant peptide receptor extracellular domain C2 antibody were specific only highly glycosylated form of the receptor, they showed a pronounced negative effect on cell motility, proliferation and activation of FGFR3-dependent signaling cascade induced by FGF2 ligand. The specificity of FGFR3 recognition by C2 in immunohistochemical analysis suggest that antibodies recognize predominantly activated form of FGFR3 receptor. Product Description popup.authors Гаріфулін Олег Мінірович Кіямова Рамзія Галямівна Овчаренко Галина Вікторівна Савінська Лілія Олексіївна Філоненко Валерій Вікторович Хоруженко Антоніна Іванівна popup.nrat_date 2020-04-02 Close