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Information × Registration Number 0214U005950, 0110U004756 , R & D reports Title The role of ion exchange membrane processes in the regulation of cyclosporine- sensitive pore and free radical reactions in mitochondria popup.stage_title Head Sagach Vadym Fedorovych, Registration Date 29-12-2014 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 The effect of mitochondrial permeability transition pore (MPTP) opening on the proton transport and matrix pH (pHi) was studied. It was shown that MPTP opening leads to the increase in transmembrane proton exchange due to the increase in K+ and Ca2+-cycling in mitochondria. The increase in potential-dependent potassium uptake results in the activation of K+/H+-exchange and the increase of proton entrance into matrix. Reciprocal dependence was observed between the increase in K+/H+-exchange and the decrease in MPTP activity due to the mitochondrial K+ATP-channel activation. The activation of transmembrane ion exchange under simultaneous opening of MPTP and K+ATP-channel leads to the uncoupling of respiratory chain and potential-independent decrease of ROS production. It was summarized that the mechanism of MPTP inhibition under K+ATP-channel opening comprises the activation of K+/H+-exchange and the suppression of ROS production. Product Description popup.authors Акопова Ольга Валеріївна Бурий Віталій Олексієвич Колчинська Людмила Іллівна Маньковська Ірина Микитівна Носарь Валентина Іванівна Сагач Вадим Федорович popup.nrat_date 2020-04-02 Close