Search academic texts

Information × Registration Number 0214U006057, 0111U003519 , R & D reports Title Pharmadynamics aspect and mechanism biocides actions polymeric derived of guanidine study popup.stage_title Head Mandygra Mykola S., Registration Date 06-02-2014 Organization Rivne Institute of Agroindustrial Production popup.description2 Possibilities of formation in model systems of persistent complexes between the molecules of salts polyhexamethyleneguanidine (PНMG) and individual lipid components of the cytoplasm membrane (CPM) were studied. Mass spectrometric studies mixtures of polycations with lipids are showed that in the liquid state, regardless of the exposure time, in the range to m/z 3000 persistent to formation of intermolecular between oligomers of PHMG and lipids are absent. Phospholipids bilayer of the CPM is the main target for the drug. The action of PНMG on the conductance of plane bilayer lipid membrane (BLM) has been investigated. The time interval required for the PGMG to adhere to the BLM and cause its eventual rupture was established to depend upon the polarization of applied potential. The application of negative membrane potential to the cis-side of BLM noticeably increased the amount of time spent before PGMG broke the membrane. The membrane surface geometry was found to influence the process of interaction with PGMG. The polycation of PHMG binds strongly with phosphoglycerides. Some lipids withdraw from participation in cellular processes. The acceleration the of new lipids synthesis and membrane-bound enzymes is likely to occure in the cell. The acceleration of phospholipid synthesis under certain conditions stimulates mitosis. We investigated the action of the member of the polyguanidine family of biocides, PHMG on seeds growing. It was shown that of all PHMG salts tested only PHMG chloride and PHMG succinate could stimulate the growing of seeds. PHMG was also capable to increase their germination and vigor. The new methods of spectrophotometry determinations of PHMG are designed. Practiced several new forms of the facilities for disinfection, is received three patents for inventions. Product Description popup.authors Андрущук Ірина Леонідівна Лисиця Андрій Валерійович Мандигра Юлія Миколаївна popup.nrat_date 2020-04-02 Close