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Information × Registration Number 0214U006219, 0111U009944 , R & D reports Title Developing new ways to heterokondensed systems and directed synthesis of compounds with anticancer properties based on them popup.stage_title Head Popov Anatolij Fedorovich, Доктор хімічних наук Registration Date 19-02-2014 Organization The L.M.Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry popup.description2 Object of study - tetrahydrobenzothieno[2,1-a] isoindole , furopirydo tetrahydrobenzo - [2,1-a] isoindole and isoquinoline containing tertiary ( bridge ) nitrogen atom. Objective - Development of methods for the synthesis of indolizine , tetrahydrobenzofuro[2,1 a] isoindole , tetrahidrobenzofuropirydo [2,1-a] isoindole using domino reactions , and isoquinoline, containing tertiary ( bridge ) nitrogen atom. Research methods - methods of organic synthesis , mass and NMR spectroscopy, X-ray analysis . Methods of obtaining tetrahydrobenzothieno [2,1-a] isoindole , tetrahidrobenzofuropirydo [2,1-a] isoindole and isoquinoline, containing tertiary ( bridge ) atom , cyclization of 2 - ( 2 -benzo [b] furan -3- ethyl) -1,3 - izoindolinildioniv and 2 [2 (aryl ) ethyl ]-1H- isoindole -1, 3 (2H)- dione with polyphosphoric acid. We found an unusual cyclization reaction of 2 - ( 2 -benzo [b] furan -3- ethyl) -1,3 izoindolinildioniv and 2 - [2 - ( aryl ) ethyl ]- 1H- isoindole -1, 3 (2H )- dione in polyphosphoric acids , accompanied Startup indolizyniyevoho intermediate cycle. A common way to build a 1 - ( 2- carboxyphenyl )- benzothieno [2,3 c] pyridines and 1,3,4,9 b- tetrahidrobenzotiyeno [2 ', 3 ': 3,4] pyrido [2,1-a] isoindole -1 ones domino reactions that occur in the cyclization of 2 - ( 3 -4- okso fenilmerkaptobutyl ) -1 , 3- izoindolindioniv in polyphosphoric acid. The behavior of 3,5- diamino -4- arylpirazoliv in the reaction Pictet -Spengler , due to which the method of obtaining derivatives aminozamischenyh pyrazolo [3,4-c] isoquinoline . Methods for introducing a molecule object of study - tetrahydrobenzothieno[2,1-a] isoindole , furopirydo tetrahydrobenzo - [2,1-a] isoindole and isoquinoline containing tertiary ( bridge ) nitrogen atom. Objective - Development of methods for the synthesis of indolizine , tetrahydrobenzothieno [2,1 a] isoindole , tetrahidrobenzofuropirydo [2,1-a] isoindole using domino reactions , and isoquinoline, containing tertiary ( bridge ) nitrogen atom. Research methods - methods of organic synthesis , mass and NMR spectroscopy, X-ray analysis . Methods of obtaining tetrahydrobenzothieno [2,1-a] isoindole , tetrahidrobenzofuropirydo [2,1-a] isoindole and isoquinoline, containing tertiary ( bridge ) atom , cyclization of 2 - ( 2 -benzo [b] furan -3- ethyl) -1,3- izoindolinildioniv and 2 [2 (aryl ) ethyl ]-1H- isoindole -1, 3 (2H)- dione with polyphosphoric acid. We found an unusual cyclization reaction of 2 - ( 2 -benzo [b] furan -3- ethyl) -1,3 izoindolinildioniv and 2 - [2 - ( aryl ) ethyl ]- 1H- isoindole -1, 3 (2H )- dione in polyphosphoric acids , accompanied Startup indolizyniyevoho intermediate cycle. A common way to build a 1 - ( 2- carboxyphenyl )- benzothieno [2,3 c] pyridines and 1,3,4,9 b- tetrahidrobenzotiyeno [2 ', 3 ': 3,4] pyrido [2,1-a] isoindole -1 ones domino reactions that occur in the cyclization of 2 - ( 3 -4- okso fenilmerkaptobutyl ) -1 , 3- izoindolindioniv in polyphosphoric acid. The paper converting 3,5 -diamine -4- arylpirazoliv in the reaction Pictet -Spengler , due to which the method of obtaining aminopohidnyh pyrazolo [3,4-c] isoquinoline . A selective glycosylation methods pyrazolo [3,4-c] isoquinoline by the phenolic hydroxyl and the nitrogen atom of the pyrazole cycle. Product Description popup.authors Абрамянц Маргарита Григорівна Білобров Володимир Мокієвич Богдан Наталя Михайлівна Богза Сергій Леонідович Дмитрук Олександр Філаретович Заречна Ольга Михайлівна Каніболоцький Олександр Леонідович Ломов Дмитро Олександрович Романцевич Андрій Михайлович Суйков Сергій Юрійович Толкунов Андрій Сергійович Толкунов Валерій Сергійович Толкунов Сергій Володимирович Тюрина Тетяна Григорівна Хабаров Костянтин Михайлович Хижан Олександр Іванович popup.nrat_date 2020-04-02 Close