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Information × Registration Number 0214U006220, 0109U008220 , R & D reports Title Stable carbenes and their metal complexes in heterocyclic synthesis and catalysis of organic reactions popup.stage_title Head Korotkikh Nikolai Ivanovich, Доктор хімічних наук Registration Date 19-02-2014 Organization The L.M.Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry popup.description2 Object of the study is antimicrobial activity of transition metal carbene complexes and carbenoids of salt type, synthesis of polynuclear carbenes and carbenoids , sulfenes , cycloaddition reactions. The purpose of the work is synthesis of transition metal carbene complexes and study of their antimicrobial activity, synthesis polynuclear carbenes and carbenoid systems, study of their properties and directions of sulfene cycloadditions. Methods of the research are synthetic , kinetic , spectral (NMR spectroscopy ) analytical, chromatoghrafical, elemental analysis ), quantum chemical. Basic results. Precarbene and metal carbene complexes of the imidazole, 1,2,4 - and 1,2,3 - triazole series (palladium, copper(I), nickel, cobalt) were synthesized by the direct action of stable carbenes to transition metal salts or via analogous in situ reactions in tetrahydrofuran. High antimicrobial activity for carbenoid salts and carbene complexes was found, which reaches MBsC 7,8 mcG/mL and MBcC 15,6 mcG/mL for imidazol-2-ylidene and nickel derivative on a test culture M. luteum, and for the cobalt complex on a test culture C. tenuis reaches MFsC 1,9 mcG/mL and MFcC 3,9 mcG/mL, correspondingly. Geometrical isomers of linear biscarbenes of the 1,2,4-triazole series and precursors in the synthesis of annulated imidazolio[4,5-d]imidazolium systems were also synthesized. It is established that the reaction of sulfenes and disulfenes with the olefin compounds containing activated electron donor substituent and Shiff bases lead to sulphur containing heterocyclic compounds, i.e. thiazetidine and thietan-1,1-dioxide derivatives as structural analogues of drugs with fungicidal and analgetic activity. The data obtained have significance for the preparative synthesis of transition metal carbene complexes with antimicrobial effect and catalysts of organic reactions, for the synthesis of sulfenes as carbene adducts. Scope of application - pharmacy , catalysis of organic reactions, the synthesis of transition metal carbene complexes, heterocyclic synthesis on the basis of sulfenes. Product Description popup.authors Єня Василь Іванович Глиняна Наталія Валеріївна Дорошенко Тетяна Федорівна Кисельов Артем Вікторович Кнішевицький Артур Володимирович Ковач Микола Анатолійович Короткіх Микола Іванович Лящук Сергій Миколайович Орлов Максим Артурович Раєнко Генадій Федорович Сабєров Вагіз Шамільйович Швайка Олесь Павлович popup.nrat_date 2020-04-02 Close