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Information × Registration Number 0214U006705, 0111U000153 , R & D reports Title Cytological mechanisms of gravitational-dependent changes in a skeleton and hemohenesis bodies at the land vertebrates popup.stage_title Head Rodionova Natalia Vasilievna, Registration Date 10-02-2014 Organization Schmalhausen Institute of Zoology popup.description2 Object of research - samples of bodies and the tissues, that were received at representatives of the 4th classes land vertebrates (amphibians, reptiles, birds, mammals). The work purpose - definition of cellular mechanisms of adaptation of a bone skeleton and the hemohenesis bodies to decrease the mechanical loadings at the land vertebrates. Research techniques: use of a complex of methods includes a histology, a histochemistry, cytochemistry, a transmission and raster electron microscopy, radioautography, culture of cellules, a morphometric and statistical analysis, programs for processing of light microscopes images. On representatives of classes (Amphibia, Reptilia, Aves, Mammalia) who differ as musculoskeletal loadings and in model experiments on mammals with removal of basic loading of extremities new data to science about structural and metabolic features of cartilaginous height zones formation and the bone formation centres, a structure of a vascular bed and its cell-like structure in a skeleton of extremities; ultastructure and specific functioning of bone tissue cells (osteoblasts, osteocytes); about dynamics of updating of cell populations and some mechanisms of adaptive remodelling of bone structures; cellular structure, ultrastructural features and gistogenetic potential of bone marrow stromal cells of the amphibians and reptiles representatives including in vitro conditions were obtained. Differences in intensity of a hemopoiesis in different departments of hemopoietic system at representatives of poikilothermal animals depending on locomotion types were investigated. Results of researches bring new in comprehension of cellular mechanisms of gravitational-dependent changes in skeleton bone tissue and the hemopoietic bodies at land vertebrata. Results of NDR have fundamental value, and also can be used in medicine when developing methods of treatment and prophylaxis of osteoporosis. Are recommended also for inclusion in training programs and textbooks on a cytology, a histology, а zoology. Keywords: bone tissue, cartilaginous tissue, cellules differentiation, hypokinesia, land vertebrates, histology, electron microscopy, radioautography, culture of cells. Product Description popup.authors Акуленко Наталія Михайлівна Житніков Анатолій Якович Золотова -Гайдамака Надія Вікторівна Родіонова Наталія Василівна Скрипченко Олена Володимирівна popup.nrat_date 2020-04-02 Close