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Information × Registration Number 0214U006898, 0111U002660 , R & D reports Title Genetic monitoring of birth defects in children of Lviv region popup.stage_title Head Hnateyko Oleh, Registration Date 05-03-2014 Organization Scientific-research institute of Hereditary pathology popup.description2 Formed Regional Registry "model " of congenital malformations in children in Lviv region for the period 2002-2013 yy based of the method of "case-control comprising 810 cases of congenital malformations in children and 803 children in the control group . Among mothers who had children with congenital malformations compared with the control set to significant (p<0.05 and above) increased frequency of stillbirths (2.5% and 0.24%, respectively), acute infectious disease 3 months before pregnancy and during pregnancy (30,2% and 15.3%), preterm delivery (22.2 % and 0%) , pathological structure of the placenta (35.1% and 15.2 %) , assessment of the child's Apgar score less than 8 points (40.7 % in lack of control ). Established in a third of cases of malformation of the gastrointestinal tract combined with anomalies of other organs and systems, leading to an increase in the severity of the basic disease: in 44.0% of infants with atresia of the anus and/or rectum in 26.7% of esophageal atresia and in 28.6% of children with atresia of the small intestine . One-third (32.7%) cases of congenital malformations of the kidneys revealed a family history regarding renal disease, indicating the importance of genetic factors in their formation. It is shown that significant teratogenic factor in the formation of congenital defects of the urinary system are the occupational hazards of parents. In women with primary infertility were observed significantly more gynecological diseases (91.1%) compared with controls (16.7%). In medical and genetic counseling of families with Lviv region, abounding cases of breast cancer, found a statistically significantly higher incidence of heart disease (12.2% and 4.9%, respectively, p <0.05). Product Description popup.authors Гельнер Надія Володимирівна Геник-Березовська Софія Олександрівна Гнатейко Олег Зіновійович Грузинцева Наталія Анатоліївна Зборовська Наталія Володимирівна Кіцера Наталія Іванівна Косминіна Неля Станіславівна Лотоцька-Савчак Оксана Юрївна Лук'яненко Наталія Сергіївна Лучак Марта Володимирівна Осадчук Зоряна Василівна Прокопчук Наталія Миколаївна Чайковська Галина Степанівна Шаргородська Євгенія Борисівна popup.nrat_date 2020-04-02 Close