Total number
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Total number
Full text
Number of local repositories
Full text
0214U006899,
0111U002659
,
The genetic approach to early diagnostics and prognosis for neoplasia occurrence at the hereditary diseases of intestine.
Hnateyko Oleh,
05-03-2014
Scientific-research institute of Hereditary pathology
The theoretic summarizing and new solution of the problem of genetic diagnostics and valuation of the significance of the hereditary factors in the prognosis of colorectal cancer occurrence in the patients of the west regions of Ukraine was carried out. The "positive" familial anamnesis was confirmed in 61(33,5%) patients with colorectal cancer. Four main genetic forms of the multiply adenomatous polyposis and the genotype-phenotype relation of these diseases were studied. It was investigated the mechanisms of the genetic instability on the chromosomal level and was accesses the role of aneuploidy and polyploidy in the intestine cancerogenesis. The algorithm of the genetic diagnostics of the intestine diseases with high risk of colorectal cancer occurrence was proposed on the basis of the received analysis.
Дулик Н.П.
Лозинська М. Р.
Чорна Л.Б.
2020-04-02
Updated: 2025-12-08
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